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Sialidase (α2-3-6-8-9)

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By Targets:	Endogenous Metabolite (5) Influenza Virus (1)
By Research Areas:	Infection (2) Inflammation/Immunology (1) Metabolic Disease (2)

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Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Neuraminidase, Microorganism Exo-α-Sialidase	Endogenous Metabolite	Infection
Neuraminidase, Microorganism (Exo-α-sialidase) is an exosialidase, is often used in biochemical studies. Neuraminidase cleaves α-ketosidic linkage between the sialic (N-acetylneuraminic) acid and an adjacent sugar residue. Neuraminidase, derived from mucosal pathogens, is a virulence factor that modifies the host's response to infection .

*Ganglioside sialidase* (AuSialidase S)** Sialidase isoenzyme S; AuSialidase S	Endogenous Metabolite	Metabolic Disease
Ganglioside sialidase (AuSialidase S) is an endogenous metabolite. Ganglioside sialidases have been implicated in neuronal differentiation processes, including neurite outgrowth .

Sialidase (α2-3-6-8-9)	Others	Others
Sialidase (α2-3-6-8-9) is a broadly specific sialidase that cuts linear and branched non-reducing terminal sialic acid residues from glycoproteins, glycopeptides, and oligosaccharides. Sialidase (α2-3-6-8-9) can be used for in vitro and in vivo polysaccharide analysis and characterization as well as complete glycoprotein remodeling .

*alpha-2-3,6-sialidase* (BiNanH2)**	Endogenous Metabolite	Metabolic Disease
alpha-2-3,6-sialidase (BiNanH2) is a sialyltransferase, is often used in biochemical studies. alpha-2-3,6-sialidase (BiNanH2) catalyzes α-2,3/2,6-sialyltransfer from CMP-Neu5Ac to galactoside acceptors .

Siastatin B	Endogenous Metabolite	Others
Siastatin B is an effective broad-spectrum glycosidase inhibitor that can effectively inhibit the activities of *sialidase, β-D-glucuronidase, N-acetyl-glucosaminidase, β-glucuronidase, and human heparinase* .

2,3-Dehydro-2-deoxy-N-acetylneuraminic acid 1 Publications Verification Neu5Ac2en; DANA	Influenza Virus	Infection
N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) is a potent neuraminidase (sialidase) inhibitor. N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid shows inhibitory activities against human neuraminidase enzymes with IC₅₀s of 143, 43, 61, and 74 μM for NEU1, NEU2, NEU3, and NEU4, respectively. Anti-influenza virus activity .

Sialyl-Lewis X sLeX	Endogenous Metabolite	Inflammation/Immunology
Sialyl-Lewis X (sLeX) is a sialylated fucosylated tetrasaccharide, an endogenous antigen. Sialyl-Lewis X is a high-affinity ligand for selectins (E-, P-, and L-selectin) . Sialyl-Lewis X binds to ELAM-1 and CD62 and has the ability to inhibits CD62-mediated neutrophil recruitment to sites of inflammation .

Species:	Virus (1) Human (2) Mouse (1)
Tag:	His (6) Myc (1)
Source:	HEK293 (2) P. pastoris (1) Sf9 insect cells (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

	Sialidase-1 Protein, Human (HEK293, His) Sialidase-1; Acetylneuraminyl Hydrolase; G9 Sialidase; Lysosomal Sialidase; N-Acetyl-Alpha-Neuraminidase 1; NEU1; NANH	Human	HEK293
	The Sialidase-1 protein plays a crucial role in cellular processes by catalyzing the removal of the sialic acid (N-acetylneuraminic acid) moiety from glycoproteins and glycolipids. Its enzymatic activity is strictly dependent on its presence in multienzyme complexes, emphasizing the cooperative nature of its function. Sialidase-1 Protein, Human (HEK293, His) is the recombinant human-derived Sialidase-1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Sialidase-1 Protein, Human (HEK293, His) is 368 a.a., with molecular weight of 39-50 kDa.

	Neuraminidase Protein, M.viridifaciens (His) Sialidase; Neuraminidase; nedA	Others	E. coli
	Neuraminidase is a subtype of sialidase associated with the pathogenic potential of microbial infections. As an enzyme, neuraminidase plays a crucial role in catalyzing the removal of terminal sialic acid residues from glycoproteins and glycolipids. Neuraminidase Protein, M.viridifaciens (His) is the recombinant Neuraminidase protein, expressed by E. coli , with N-His labeled tag. The total length of Neuraminidase Protein, M.viridifaciens (His) is 362 a.a., with molecular weight of ~39.7 kDa.

	Neuraminidase Protein, C.perfringens (His) Sialidase; Neuraminidase; nanH	Virus	E. coli
	Neuraminidase is a subtype of sialidase associated with the pathogenic potential of microbial infections. As an enzyme, neuraminidase plays a crucial role in catalyzing the removal of terminal sialic acid residues from glycoproteins and glycolipids. Neuraminidase Protein, C.perfringens (His) is the recombinant Virus-derived Neuraminidase protein, expressed by E. coli , with N-His labeled tag. The total length of Neuraminidase Protein, C.perfringens (His) is 381 a.a., with molecular weight of ~40 kDa.

	Sialidase-2 Protein, Mouse (P.pastoris, His) Neu2; Sialidase-2; EC 3.2.1.18; Cytosolic Sialidase; Mouse skeletal muscle Sialidase; MSS; Murine thymic Sialidase; MTS; N-acetyl-alpha-neuraminidase 2	Mouse	P. pastoris

	NEU2 Protein, Human (HEK293, His) Sialidase-2; Cytosolic Sialidase; N-acetyl-alpha-neuraminidase 2; NEU2	Human	HEK293
	NEU2 protein acts as an exo-α sialidase and selectively hydrolyzes terminal sialic acids in glycolipids, glycoproteins, and oligosaccharides. It shows specificity for α-(2->3)-sialylated GD1a and GT1B gangliosides, preferring α-(2->3) over α-(2->8)-sialylated GD1b. NEU2 Protein, Human (HEK293, His) is the recombinant human-derived NEU2 protein, expressed by HEK293 , with C-His labeled tag. The total length of NEU2 Protein, Human (HEK293, His) is 380 a.a., with molecular weight of ~43.7 kDa.

	NEU2 Protein, Cricetulus griseus (Baculovirus, His-Myc) NEU2; Sialidase-2; EC 3.2.1.18; Cytosolic Sialidase; N-acetyl-alpha-neuraminidase 2	Others	Sf9 insect cells
	The NEU2 protein plays a key role in cellular processes by catalyzing the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins, oligosaccharides, and gangliosides. Through its enzymatic activity, NEU2 contributes to the controlled modification of cell surface glycoconjugates, affecting various cellular functions including cell adhesion, signaling, and immune responses. NEU2 Protein, Cricetulus griseus (Baculovirus, His-Myc) is the recombinant NEU2 protein, expressed by Sf9 insect cells , with N-10*His, C-Myc labeled tag. The total length of NEU2 Protein, Cricetulus griseus (Baculovirus, His-Myc) is 379 a.a., with molecular weight of ~45.8 kDa.

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